Choosing antipsychotic drugs in schizophrenia
نویسندگان
چکیده
منابع مشابه
Antipsychotic drugs for relapse prevention in schizophrenia.
www.thelancet.com Vol 380 September 22, 2012 1055 trial requires it to be viewed in the context of the totality of evidence; the estimates of eff ect seen in IST-3 were comparable with, and reinforced the results of, previous trials. Fatovich and colleagues state that we had decided “ordinal analysis was not appropriate”; this was the view of the steering committee in 2009. However, as stated i...
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Chlorpromazine, which was discovered in 1952, has an exhaustively characterized efficacy/safety profile comprising serious limitations: effectiveness in the field failing to match efficacy in trials, residual symptoms in 50% of patients, a 20% relapse rate in compliant patients, and worrisome extrapyramidal side effects, including tardive dyskinesia in 5% per year. Second-generation "atypical" ...
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The Cognitive Deficit in Schizophrenia Schizophrenia was originally called dementia praecox by Emil Kraepelin, the great 19th century psychiatric nosologist, who coined the term to categorize a group of young psychotic patients who went on to develop dementia. A decade later, Eugen Bleuler, noting that most patients who had similar psychotic and affective features did not become severely dement...
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BACKGROUND The symptoms and signs of schizophrenia have been firmly linked to high levels of dopamine in specific areas of the brain (limbic system). Antipsychotic drugs block the transmission of dopamine in the brain and reduce the acute symptoms of the disorder. This review examined whether antipsychotic drugs are also effective for relapse prevention. OBJECTIVES To review the effects of ma...
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We describe in schizophrenia the alterations of classical neurotransmitters and neuropeptides in the mesolimbic system, the hippocampus and the prefrontal cortex. The susceptibility genes, which encode dopamine hyperactivity and glutamate and GABA hyperactivity, are described. Using a neural network in the mesolimbic system, the coherence between the risk genes and the cellular mechanisms is de...
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ژورنال
عنوان ژورنال: Psychiatric Bulletin
سال: 2001
ISSN: 0955-6036,1472-1473
DOI: 10.1192/pb.25.8.284